DETAIL KOLEKSI

Hubungan kadar serum ferritin dengan pertumbuhan fisik penderita thalassemia mayor


Oleh : Isthi Dyah Pangesti

Info Katalog

Nomor Panggil : 616.152/PAN/h

Penerbit : FK - Usakti

Kota Terbit : Jakarta

Tahun Terbit : 2015

Pembimbing 1 : Henie Widowati

Subyek : Thalassemia

Kata Kunci : thalassemia major, serum ferritin, physical growth.


File Repositori
No. Nama File Ukuran (KB) Status
1. 2015_TA_SKD_03011142_Halaman-judul.pdf 2332.66
2. 2015_TA_SKD_03011142_Pengesahan.pdf 724.67
3. 2015_TA_SKD_03011142_Bab-1_Pendahuluan.pdf 734.4
4. 2015_TA_SKD_03011142_Bab-2_Tinjauan-literatur.pdf 868.69
5. 2015_TA_SKD_03011142_Bab-3_Kerangka-konsep.pdf 714.8
6. 2015_TA_SKD_03011142_Bab-4_Metode.pdf 876.73
7. 2015_TA_SKD_03011142_Bab-5_HAsil.pdf 808.93
8. 2015_TA_SKD_03011142_Bab-6_Pembahasan.pdf 723.49
9. 2015_TA_SKD_03011142_Bab-7_Kesimpulan.pdf 696.58
10. 2015_TA_SKD_03011142_Daftar-pustaka.pdf 703.81
11. 2015_TA_SKD_03011142_Lampiran.pdf 1484.96

K Kelebihan besi merupakan konsekuensi klinis jangka panjang akibat tatalaksanapada Talasemia yang mempengaruhi kualitas hidup penderitanya. Kelebihan besidapat menimbulkan gangguan tumbuh kembang seperti perawaan pendek danpubertas terlambat. Penelitian dilakukan untuk mengetahui distribusi dari tinggibadan, kecepatan tumbuh, dan status pubertas serta hubungan ketiganya dengankadar ferritin serum pada penderita Talasemia mayor.METODEStudi observasional dengan desain potong lintang dilakukan pada bulanNovember – Januari 2015 mengikutsertakan 114 penderita Talasemia mayorberobat jalan yang berkunjung di Klinik Talasemia RSUD Kabupaten Tangerang,Banten. Subjek dikumpulkan secara consecutive non-random sampling. Datakarakteristik subjek, kecepatan tumbuh dan feritin serum satu tahun terakhirdiambil dari rekam medis. Cut-off feritin serum 2500 ng/mL. Setiap subjekpenelitian dilakukan pengukuran tinggi badan dan status pubertas menggunakanskala Tanner sebagai data primer. Analisis statistik dilakukan dengan uji Chisquaredengan tingkat kemaknaan p<0,05.HASILRerata kadar ferritin serum 2935±1352 ng/dL, sebanyak 74 orang (64,9%)mempunyai kadar ferritin serum >2500 ng/dL. Rerata ferritin serum pada subjeklaki-laki 2892,75 ng/dL dan perempuan 3001 ng/dL. Sebagian besar penderitaTalasemia berperawakan pendek (69,3%), mempunyai kecepatan tumbuhmenurun (28,1%), dan mengalami keterlambatan pubertas menurut skala Tanner(5,3%). Analisa uji Chi-square menunjukkan tidak terdapat hubungan yangbermakna secara statistik antara kadar ferritin serum dengan tinggi badan(p=0,906), kecepatan tumbuh (p=0,889), status pubertas (p=1,00).KESIMPULANTidak terdapat hubungan yang signifikan antara kadar ferritin serum dengan tinggibadan, kecepatan tumbuh dan status pubertas.

I Iron overload is one of the long term clinical consequences that affect quality oflife due to management of Thalassemia. Growth disturbances, such as shortstature and delayed puberty is one of the consequences of iron overload in thesufferer. This study was conducted to determine the distribution of height, growthrate and puberty and its relationship with Ferritin Serum in patients withThalassemia major.MATERIAL AND METHODSAn observational-analytic study with cross-sectional design was conducted onNovember to January 2015, 114 patients aged 10-18 years old with Thalassemiamajor who visited for outpatient in Thalassemia Clinic Hospital in Tangerang,Banten was non-randomized consecutively taken were included in the study. Dataon the characteristics of the subjects, growth velocity and serum ferritin weretaken from the medical records. Cut off serum ferritin is 2500 ng/mL. Eachsubject will be doing the measurement of height and pubertal stage using theTanner scale. Statistical analysis was performed with Chi-square test using 0.05significance level.RESULTSMean Ferritin Serum in all subject was 2935±1352 ng/dL,64,9% had meanFerritin Serum >2500 ng/dL, in male subject 2892,75 ng/dL and female subject3001 ng/dL. Obtained 69.3% of the subjects Talasemia was short, 28.1% had adecreased growth rate and 5.3% of the subjects experienced a delay pubertyaccording to Tanner scale. Analysis of the Chi-square test showed that there wasno statistically significant relationship between Ferritin Serum levels with height(p = 0.906), growth rate (p = 0.889) and pubertal status (p = 1.00).CONCLUSIONThere is no significant correlation between serum ferritin levels with height, speedof growth and pubertal status.

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